Product Usage: This product is intended as a research chemical only. This designation permits the use of research chemicals strictly for in vitro testing and laboratory research, but not for human or animal.. This product should only be handled by licensed, qualified professionals. All information available on this website is for educational purposes only. This product is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as such. Acknowledged to the Terms and Conditions, the customer hereby agrees to take full responsibility on how to use the product.
Description
xCOG1410 ApoE Mimetic Peptide | Neuroprotective & Anti-Inflammatory Research Peptide
Product Name: COG1410
Synonym: ApoE Mimetic Peptide
CAS Number: 878009-24-6
Molecular Formula: C₆₄H₁₂₁N₂₁O₁₄
Molecular Weight: 1408.78 g/mol
Sequence: Ac-AS-{Aib}-LRKL-{Aib}-KRLL-NH₂
Purity: ≥98%
Appearance: Solid, white to off-white
What is COG1410?
COG1410 ApoE mimetic peptide is a synthetic peptide derived from the receptor-binding region of apolipoprotein E (ApoE). It is structurally enhanced with alpha-aminoisobutyric acid (Aib) residues for increased stability and bioactivity. This research peptide is known for its neuroprotective and anti-inflammatory effects, making it ideal for preclinical investigation into brain health, traumatic brain injury (TBI), stroke, and neurodegenerative diseases.
COG1410 Peptide Anti-Inflammatory Uses
● Neuroinflammation Reduction: COG1410 has demonstrated the ability to modulate inflammation in brain tissues following traumatic brain injury and ischemic events.
● Oxidative Stress Control: It reduces oxidative damage and cellular apoptosis in neuronal environments.
● Cognitive Recovery Support: Shows promise in improving neurological outcomes post-TBI in animal models.
● Immunomodulatory Effects: Helps balance pro- and anti-inflammatory cytokines in the central nervous system.
COG1410 for Brain Health Research
Used extensively in neurological research, COG1410 plays a key role in investigating:
● Traumatic Brain Injury (TBI)
● Cerebral ischemia and stroke
● Alzheimer’s and neurodegenerative conditions
● Neuroimmune interactions
Its design enables crossing of the blood-brain barrier, a vital feature for brain-targeted therapeutic research.
COG1410 vs COG112 Peptide Comparison
While both peptides are derived from ApoE and share anti-inflammatory and neuroprotective characteristics:
● COG112 includes a cell-penetrating peptide (CPP) sequence to enhance intracellular delivery.
● COG1410, with its Aib-modified backbone, offers increased resistance to enzymatic degradation and sustained bioactivity.
Researchers may choose COG1410 for longer-lasting effects and targeted action in neuroinflammatory models.
Storage & Handling
● Powder:
○ −80°C: 3 years
○ −20°C: 2 year
● In Solution (sealed, nitrogen-protected):
○ −80°C: 1 year
○ −20°C: 6 months
● Shipping: Room temperature (within continental US)
Specifications
|
Property |
Value |
|
Form |
Solid |
|
Color |
White to off-white |
|
Purity |
>98% |
|
Solubility |
Soluble in water or buffer solutions |
|
Application |
Research use only (not for injection or human use) |
Where to Buy COG1410 Peptide
Where to buy COG1410 peptide online? We provide high-purity, research-grade COG1410 ApoE mimetic peptide, available in bulk or small quantities for laboratories, universities, and R&D professionals. Ideal for formulations in brain injury, stroke, and neuroinflammation research.
Shipping & Return
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Shipping
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Disclaimer
xAll articles and product information provided on this website are for informational and educational purposes only. The products offered on Qualitides are intended solely for in-vitro research purposes. In-vitro studies ("in glass" studies) are conducted outside of the body. These products are not medicines or drugs and have not been evaluated or approved by the FDA to prevent, treat, diagnose, or cure any medical condition, ailment, or disease. Any form of bodily introduction or administration of these products into humans or animals is strictly prohibited by law. By using this website, you acknowledge and agree to comply with all applicable regulations and restrictions related to the products provided by Qualitides.
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