COG1410 ApoE Mimetic Peptide

Name: COG1410, ApoE Mimetic Peptide
SKU: QT-2007
Price: 199 USD
Availability: InStock
Author: George Lee

COG1410 ApoE Mimetic Peptide | Neuroprotective & Anti-Inflammatory Research Peptide

Product Name: COG1410
Synonym: ApoE Mimetic Peptide
CAS Number: 878009-24-6
Molecular Formula: C₆₄H₁₂₁N₂₁O₁₄
Molecular Weight: 1408.78 g/mol
Sequence: Ac-AS-{Aib}-LRKL-{Aib}-KRLL-NH₂
Purity: ≥98%
Appearance: Solid, white to off-white

What is COG1410?

COG1410 is an Apolipoprotein E-mimetic peptide developed by Cognosci, Inc. It is a synthetic peptide derived from the receptor-binding region of apolipoprotein E (ApoE), which is structurally enhanced with alpha-aminoisobutyric acid (Aib) residues for increased stability and bioactivity. This research peptide is known for its neuroprotective and anti-inflammatory effects, making it ideal for preclinical investigation into brain health, traumatic brain injury (TBI), stroke, and neurodegenerative diseases.

COG1410: Anti-Inflammatory Peptide

Neuroinflammation Reduction: COG1410 has demonstrated the ability to modulate inflammation in brain tissues following traumatic brain injury[1-5] and ischemic events[4, 6-8].
Oxidative Stress Control: It reduces oxidative damage and cellular apoptosis in neuronal environments[9, 10].
Cognitive Recovery Support: Shows promise in improving neurological outcomes post-TBI in animal models.
Immunomodulatory Effects: Helps balance pro- and anti-inflammatory cytokines in the central nervous system.
Anti-Microbial Activity:

COG1410 for Brain Health Research

Used extensively in neurological research, COG1410 plays a key role in investigating:

Traumatic Brain Injury (TBI) [1-5]
Cerebral ischemia and stroke [4, 6-8]
Alzheimer’s and neurodegenerative conditions
Neuroimmune interactions

Its design enables crossing of the blood-brain barrier, a vital feature for brain-targeted therapeutic research.

COG1410 vs COG112 Peptide Comparison

While both peptides are derived from ApoE and share anti-inflammatory and neuroprotective characteristics:

COG112 includes a cell-penetrating peptide (CPP) sequence to enhance intracellular delivery.
COG1410, with its Aib-modified backbone, offers increased resistance to enzymatic degradation and sustained bioactivity.

Researchers may choose COG1410 for longer-lasting effects and targeted action in neuroinflammatory models.

Storage & Handling

Powder:

○ −80°C: 3 years

○ −20°C: 2 year

In Solution (sealed, nitrogen-protected):

○ −80°C: 1 year

○ −20°C: 6 months

Shipping: Room temperature (within continental US)

Specifications

Property	Value
Form	Solid
Color	White to off-white
Purity	>98%
Solubility	Soluble in water or buffer solutions
Application	Research use only (not for injection or human use)

Where to Buy COG1410 Peptide

Where to buy COG1410 peptide online? Qualitide provide high-purity, research-grade COG1410 ApoE mimetic peptide, available in bulk or small quantities for laboratories, universities, and R&D professionals. Ideal for formulations in brain injury, stroke, and neuroinflammation research.

References:

Chiu, L.S., Anderton, R.S., Cross, J.L., Clark, V.W., Edwards, A.B., Knuckey, N.W. & Meloni, B.P., Assessment of R18, COG1410, and APP96-110 in Excitotoxicity and Traumatic Brain Injury. Transl Neurosci, 2017. 8: p. 147-157.
Hoane, M.R., Pierce, J.L., Holland, M.A., Birky, N.D., Dang, T., Vitek, M.P. & McKenna, S.E., The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury. J Neurotrauma, 2007. 24(7): p. 1108-18.
Laskowitz, D.T., McKenna, S.E., Song, P., Wang, H., Durham, L., Yeung, N., Christensen, D. & Vitek, M.P., COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. J Neurotrauma, 2007. 24(7): p. 1093-107.
Cao, F., Jiang, Y., Wu, Y., Zhong, J., Liu, J., Qin, X., Chen, L., Vitek, M.P., Li, F., Xu, L. & Sun, X., Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury. J Neurotrauma, 2016. 33(2): p. 175-82.
Yan, J., Zhang, Y., Wang, L., Li, Z., Tang, S., Wang, Y., Gu, N., Sun, X. & Li, L., TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice. J Neuroinflammation, 2022. 19(1): p. 289.
Tukhovskaya, E.A., Yukin, A.Y., Khokhlova, O.N., Murashev, A.N. & Vitek, M.P., COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia. Journal of neuroscience research, 2009. 87(3): p. 677-82.
Wang, H., Anderson, L.G., Lascola, C.D., James, M.L., Venkatraman, T.N., Bennett, E.R., Acheson, S.K., Vitek, M.P. & Laskowitz, D.T., ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Exp Neurol, 2013. 241: p. 67-74.
Zhao, R., He, T., Xing, Y. & Luo, J., COG1410 regulates microglial states and protects retinal ganglion cells in retinal ischemia-reperfusion injury. Exp Eye Res, 2023: p. 109678.
Pang, J., Peng, J., Matei, N., Yang, P., Kuai, L., Wu, Y., Chen, L., Vitek, M.P., Li, F., Sun, X., Zhang, J.H. & Jiang, Y., Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice. Transl Stroke Res, 2018. 9(6): p. 654-668.
Peng, J., Pang, J., Huang, L., Enkhjargal, B., Zhang, T., Mo, J., Wu, P., Xu, W., Zuo, Y., Peng, J., Zuo, G., Chen, L., Tang, J., Zhang, J.H. & Jiang, Y., LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats. Redox Biol, 2019. 21: p. 101121.

Disclaimer:

All products are sold strictly for laboratory research purposes only. Not for human or veterinary use, consumption, therapeutic, or diagnostic application. By purchasing, you confirm you are a qualified professional and legally permitted to handle these materials in compliance with all applicable laws and regulations. Misuse, resale for unauthorized purposes, or unlawful application is strictly prohibited. Qualitide disclaims all liability for improper use, handling, or regulatory non-compliance.

Weight	1 oz
Size	10 MG, 2 MG

COG1410, ApoE Mimetic Peptide