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Product Usage: This product is intended as a research chemical only. This designation permits the use of research chemicals strictly for in vitro testing and laboratory research, but not for human or animal.. This product should only be handled by licensed, qualified professionals. All information available on this website is for educational purposes only. This product is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as such. Acknowledged to the Terms and Conditions, the customer hereby agrees to take full responsibility on how to use the product.
COG112 ApoE Mimetic Peptide | Anti-Inflammatory & Neuroprotective Research Peptide
Product Overview:
COG112 is a synthetic Apolipoprotein E (ApoE) mimetic peptide designed by conjugating the receptor-binding domain of ApoE (COG133) with the cell-penetrating peptide (CPP) antennapedia (Antp). This modification significantly enhances the peptide’s anti-inflammatory properties and neuroprotective effects compared to COG133 alone.
Sequence:
acetyl-YRQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-amide
Molecular Formula:
C202H347N71O38S2
Molecular Weight:
4460.51 g/mol
Key Features and Uses:
● ApoE mimetic peptide COG112 is extensively studied for its ability to modulate inflammatory responses, primarily by inhibiting the NF-κB signaling pathway.
●Exhibits potent anti-inflammatory properties useful for research into neurodegenerative diseases and inflammatory bowel disease.
● Compared to the original ApoE peptide COG133, COG112 demonstrates enhanced cell penetration and therapeutic efficacy due to the CPP antennapedia conjugation.
● Recent research highlights the role of COG112 in cancer biology by inhibiting the SET-Rac1 interaction, resulting in decreased cancer cell migration and invasion.
● COG112 peptide is widely used in anti-inflammatory uses and ApoE peptide research studies to explore novel therapeutic applications.
Research Insights:
● COG112 vs COG133 ApoE peptide: The addition of the CPP domain in COG112 dramatically improves cellular uptake and anti-inflammatory activity compared to COG133 alone, making it a superior candidate for experimental therapies targeting inflammation and neuroprotection.
●Potential applications include modulation of inflammatory bowel disease, neurodegenerative disorders such as Alzheimer’s disease, and oncology research focused on tumor invasion and metastasis.
Product Applications:
Ideal for scientists and researchers investigating:
● Inflammatory signaling pathways (e.g., NF-κB inhibition)
● Neuroprotection mechanisms
● Cancer cell migration and invasion pathways
● Novel peptide therapeutics development
CAS #: NA
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At QUALITIDE, we aim to make your shopping experience simple and smooth. Here’s how we handle shipping: Processing Time We process all orders within 0 to 1 business day. Orders placed after business hours, on weekends, or on holidays will be processed the next business day. Delivery Time Once processed, delivery takes 2 to 3 business days, depending on your location and the shipping carrier. Total Delivery Time From placing your order to receiving it, the total time is 2 to 4 business days, including both processing and shipping.
All articles and product information provided on this website are for informational and educational purposes only. The products offered on Qualitides are intended solely for in-vitro research purposes. In-vitro studies ("in glass" studies) are conducted outside of the body. These products are not medicines or drugs and have not been evaluated or approved by the FDA to prevent, treat, diagnose, or cure any medical condition, ailment, or disease. Any form of bodily introduction or administration of these products into humans or animals is strictly prohibited by law. By using this website, you acknowledge and agree to comply with all applicable regulations and restrictions related to the products provided by Qualitides.
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