Product Usage: This product is intended as a research chemical only. This designation permits the use of research chemicals strictly for in vitro testing and laboratory research, but not for human or animal.. This product should only be handled by licensed, qualified professionals. All information available on this website is for educational purposes only. This product is not a drug, food, or cosmetic and may not be misbranded, misused, or mislabeled as such. Acknowledged to the Terms and Conditions, the customer hereby agrees to take full responsibility on how to use the product.
Description
xCOG133 ApoE Mimetic Peptide – Neuroprotective & Anti-Inflammatory Agent
COG133 is a synthetic ApoE mimetic peptide derived from the receptor-binding region of apolipoprotein E. It exhibits potent anti-inflammatory, neuroprotective, and cognitive-supportive effects, making it a key research peptide in neurodegenerative disease models and neuroimmune regulation.
COG133 Peptide for Cognitive Health
COG133 acts via the low-density lipoprotein receptor-related protein (LRP) pathway and demonstrates promising applications in neurobiology, especially:
- Suppressing neuroinflammation
- Reducing demyelination
- Supporting cognitive resilience
In studies on experimental autoimmune encephalomyelitis (EAE)—a model of multiple sclerosis—COG133 significantly reduced clinical symptoms and spinal cord inflammation. This highlights its relevance for cognitive health and neuroinflammatory research.
COG133 Anti-Inflammatory Effects
- Modulates CNS inflammation by targeting immune cell infiltration
- Reduces pro-inflammatory cytokines, helping preserve myelin integrity
- Shows activity as a non-competitive α7 nicotinic acetylcholine receptor antagonist with an IC₅₀ of 445 nM
- Useful in inflammation-related neurological studies
COG133 vs COG112 Peptide Comparison
While both are derived from ApoE peptides, COG133 and COG112 differ in design and application:
- COG133: LRP-dependent pathway, potent anti-inflammatory and cognitive protection
-
COG112: COG133 + penetratin sequence for improved BBB permeability
For applications not requiring direct CNS delivery, COG133 peptide offers a cleaner, focused mechanism of action.
Technical Specifications
- Peptide Name: COG133
- Sequence: Ac-LRVRLASHLRKLRKRLL-NH₂
- Molecular Formula: C₉₇H₁₈₁N₃₇O₁₉
- Molecular Weight: 2169.73 g/mol
- CAS Number: 514200-66-9
- PubChem CID: 16201427
- Purity: ≥95% (HPLC-verified)
- Storage: –20°C (long-term)
Applications
- Neuroinflammation research
- Multiple sclerosis models (EAE)
- Cognitive impairment and memory studies
- ApoE receptor pathway investigations
- Anti-inflammatory peptide drug development
Buy COG133 Peptide Online
Looking for high-purity COG133 ApoE mimetic peptide? We offer lab-tested, research-grade material ready for:
- Academic and pharmaceutical R&D
- Preclinical neuroimmune and cognitive health research
- In vitro and in vivo experiments
Buy COG133 peptide online today and support your next breakthrough in peptide-based neuroscience.
Shipping & Return
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Disclaimer
xAll articles and product information provided on this website are for informational and educational purposes only. The products offered on Qualitides are intended solely for in-vitro research purposes. In-vitro studies ("in glass" studies) are conducted outside of the body. These products are not medicines or drugs and have not been evaluated or approved by the FDA to prevent, treat, diagnose, or cure any medical condition, ailment, or disease. Any form of bodily introduction or administration of these products into humans or animals is strictly prohibited by law. By using this website, you acknowledge and agree to comply with all applicable regulations and restrictions related to the products provided by Qualitides.
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