Nonapeptide-1

What is Nonapeptide-1?
Nonapeptide-1, also known as Melanostatine™, is a synthetic biomimetic peptide designed to reduce melanin production in the skin. Acting as an antagonist of α-MSH (melanin-stimulating hormone), it blocks the activation of MC1-R receptors on melanocytes, effectively decreasing melanin synthesis and promoting a lighter, more even complexion.

How Nonapeptide-1 Works

1. MC1-R Receptor Blocking:
   Nonapeptide-1 mimics a part of the α-MSH sequence (H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂) and competes with α-MSH for binding to MC1-R receptors. This prevents receptor activation, reducing melanin production by up to 33%.

2. Inhibition of Tyrosinase Activity:
   By preventing the activation of tyrosinase, a key enzyme in melanogenesis, Nonapeptide-1 halts the biochemical process that leads to pigment formation.

3. Targeted Skin Lightening:
   Unlike harsh depigmenting agents, Nonapeptide-1 does not completely inhibit melanogenesis, preserving natural melanocyte function while preventing excess pigment production.

Key Benefits

• Reduces Hyperpigmentation: Diminishes dark spots, sunspots, freckles, and uneven pigmentation.
• Skin Lightening: Promotes a lighter and more radiant complexion.
• Even Skin Tone: Equalizes skin tone, reducing visible discoloration.
• Safe and Non-Toxic: Does not harm melanocytes or interfere with their natural functions.
• Rapid Results: Clinically proven to show significant improvements in hyperpigmentation within 28 days.

Functions

• Skin Whitening Agent: Reduces melanin production for a lighter complexion.
• Skin Conditioning: Improves skin texture and tone.
• Hair Conditioning: Used in hair care applications for enhancing scalp health.

Clinical Applications

Nonapeptide-1 is ideal for use in:

• Skin Lightening Products: Creams, serums, and lotions targeting pigmentation.
• Hyperpigmentation Treatments: Formulations addressing sunspots, melasma, and freckles.
• Post-Sun Exposure Products: Reduces sun-induced dark spots.
• Hair Care Products: Helps condition and enhance scalp health.

Technical Information

• Synonyms: Melanostatine™
• CAS Number(s): 158563-45-2
• FDA UNII: 64W45420K5

Why Choose Nonapeptide-1?

Nonapeptide-1 is a scientifically backed, safe, and effective solution for reducing hyperpigmentation and promoting an even skin tone. Its ability to selectively inhibit melanin overproduction without cytotoxicity makes it a standout ingredient in modern skin and hair care formulations.